|Place of Origin:||China|
|Model Number:||PFS, 0.2 ml/2050IU, 0.3 ml/3075IU, 0.4 ml/4100IU, 0.6 ml/6150IU, 0.8 ml/8200IU|
|Minimum Order Quantity:||5000boxes|
|Payment Terms:||L/C, T/T|
|Supply Ability:||20, 000 boxes per day|
|Product:||Nadroparin Calcium Injection Pre-filled Syringe||Specification:||PFS, 0.2 Ml/2050IU, 0.3 Ml/3075IU, 0.4 Ml/4100IU, 0.6 Ml/6150IU, 0.8 Ml/8200IU|
|Standard:||In - House||Packing:||2’s/box|
Pre Filled Syringe Small Volume Parenteral Nadroparin Calcium Injection
Product : Nadroparin Calcium Injection Pre-filled Syringe
Specification : PFS, 0.2 ml/2050IU, 0.3 ml/3075IU, 0.4 ml/4100IU, 0.6 ml/6150IU, 0.8 ml/8200IU
Standard : In - house
Packing : 2’s/box
Nadroparin is a low molecular weight heparin (LMWH) which, when bound to antithrombin III (ATIII), accelerates the inactivation of factor II and factor Xa. Nadroparin halts the coagulation pathway by inhibiting the activation of thrombin (factor IIa) by factor Xa. The amplification of the fibrin clotting cascade is stopped once factors Xa and IIa are inactivated. It is derived from porcine sources and has a mean molecular size of 5000 daltons. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
Indication and dosage
Nadroparin is used for prophylaxis of thromboembolic disorders and general surgery in orthopedic surgery, treatment of deep vein thrombosis, prevention of clotting during hemodialysis and treatment of unstable angina and non-Q wave myocardial infarction
Unstable Angina: Adults: The dose is based on body weight. It is usually 86 anti-factor Xa International Units (IU) per kilogram (kg) (39.1 anti-factor Xa IU per pound) of body weight injected under the skin every twelve hours for six days.
Venous thromboembolism and Pulmonary Embolism:
Adults: The dose is usually 2850 anti-factor Xa IU injected under the skin once a day beginning two to four hours before surgery and continuing for at least seven days.
Nadroparin is a low molecular weight heparin that is composed of a heterogeneous mixture of sulfated polysaccaride glycosaminoglycan chains. Th mean molecular weight is approximately 4300 daltons. The ratio of anti-Xa activity to anti-IIa is 3.5:1 whereas it is about 1:1 for heparin. Its use should be avoided in patients with a creatinine clearance less than 40mL/min. In these patients, unfractionated heparin should only be used. As for monitoring, active partial thromboplastin time (aPTT) will only increase at high doses of low molecular weight heparins (LMWH). Therefore, monitoring aPTT is not recommended. However, anti-Xa activity can be measured to monitor the efficacy of the LMWH.
Mechanism of action
The mechanism of action for nadroparin is similar to all other LMWHs. Like all LMWHs, nadroparin has a pentasaccharide sequence which binds to ATIII, which potentiates the action of ATIII. This complex greatly accelerates the inactivation of factor Xa and factor IIa. As a result, the coagulation cascade is inhibited.