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Eye / Ear Gentamycin Drops 0.4% 10ml Ophthalmic Preparations Antibiotic

Eye / Ear Gentamycin Drops 0.4% 10ml Ophthalmic Preparations Antibiotic

Eye / Ear Gentamycin Drops 0.4% 10ml Ophthalmic Preparations Antibiotic

Product Details:

Place of Origin: China
Brand Name: Newlystar
Certification: GMP
Model Number: 0.4% 10ml

Payment & Shipping Terms:

Minimum Order Quantity: 200, 000 bottles
Price: Negotiation
Packaging Details: one bottle/box
Delivery Time: 45 days
Payment Terms: L/C, T/T
Supply Ability: 400, 000 bottles per day
Detailed Product Description
Strength: 0.4% 10ml Packing: One Bottle/box
Dosage Form: Eye Drop Active Ingredients: Gentamycin Sulfate

Eye / Ear Gentamycin Drops 0.4% 10ml Ophthalmic Preparations Antibiotic

 

 

Product : Gentamycin Sulfate Eye & Ear Drops,

Doage and strength : Drops, 0.4% 10ml

Packaging : 1bottle/box

Standard : USP/BP

Dossier : Ready to submit

 

Description :

Gentamicin Sulfate, a water-soluble antibiotic of the aminoglycoside group, is derived by the growth of Micromonospora purpurea, an actinomycete.

 

Indication

For treatment of serious infections caused by susceptible strains of the following microorganisms: P. aeruginosa, Proteus species (indole-positive and indole-negative), E. coli, Klebsiella-Enterobactor-Serratia species, Citrobacter species and Staphylococcus species (coagulase-positive and coagulase-negative).

 

Pharmacodynamics

Gentamicin is a broad spectrum aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.

 

Mechanism of action

Aminoglycosides like gentamicin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically gentamicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

 

Contact Details
Newlystar (Ningbo) Medtech Co.,Ltd.

Contact Person: Luke Liu

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