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Antiplatelet Oral Medications Paracetamol Pain Relief Acetaminophen Tablets

Antiplatelet Oral Medications Paracetamol Pain Relief Acetaminophen Tablets

    • Antiplatelet Oral Medications Paracetamol Pain Relief Acetaminophen Tablets
  • Antiplatelet Oral Medications Paracetamol Pain Relief Acetaminophen Tablets

    Product Details:

    Place of Origin: China
    Brand Name: Newlystar
    Certification: GMP
    Model Number: 100mg, 300mg, 500mg

    Payment & Shipping Terms:

    Minimum Order Quantity: Five million tablets
    Price: Negotiation
    Packaging Details: 10's/blister
    Delivery Time: 45days
    Payment Terms: L/C, T/T
    Supply Ability: One million pills per day
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    Detailed Product Description
    Product: Paracetamol Tablets Acetaminophen Tablets Specification: 100mg, 300mg, 500mg
    Standard: BP, USP Packing: 10's/blister
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    Antiplatelet Oral Medications Paracetamol Pain Relief Acetaminophen Tablets

     

     

     

    Product : Paracetamol Tablets Acetaminophen Tablets

    Specification : 100mg, 300mg, 500mg

    Standard : BP, USP

    Packing : 10's/blister

     

    Description :

    Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.

     

    Indication

    For temporary relief of fever, minor aches, and pains.

     

    Pharmacodynamics

    Acetaminophen (USAN) or Paracetamol (INN) is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or accidental overdoses are not uncommon. Acetaminophen, unlike other common analgesics such as aspirin and ibuprofen, has no anti-inflammatory properties or effects on platelet function, and it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs or NSAIDs. At therapeutic doses acetaminophen does not irritate the lining of the stomach nor affect blood coagulation, kidney function, or the fetal ductus arteriosus (as NSAIDs can). Like NSAIDs and unlike opioid analgesics, acetaminophen does not cause euphoria or alter mood in any way. Acetaminophen and NSAIDs have the benefit of being completely free of problems with addiction, dependence, tolerance and withdrawal. Acetaminophen is used on its own or in combination with pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, doxylamine, codeine, hydrocodone, or oxycodone.

     

    Mechanism of action

    Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.

    Contact Details
    Newlystar (Ningbo) Medtech Co.,Ltd.

    Contact Person: Luke Liu

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