|801-2, Jindong Mansion, No. 536 Xueshi Road, Yinzhou, Ningbo 315100, P.R.Chinafirstname.lastname@example.org|
|Place of Origin:||China|
|Model Number:||80mg/2ml, 40mg/1ml|
|Minimum Order Quantity:||300000 amps|
|Packaging Details:||10 x 10amps/box|
|Delivery Time:||45 days|
|Payment Terms:||L/C, T/T|
|Supply Ability:||One million amps per day|
|Strength:||80mg/2ml, 40mg/2ml||Packing:||10 X 10 Amps/box, 10 Amps/box|
|Dosage Form:||Small Volume Injection||Active Ingredients:||Gentamycin Sulfate|
small volume injection,
Gentamycin Sulfate Injection Small Volume Parenteral Antibiotics 40mg/2ml 80mg/2ml
Product name : Gentamycin Sulfate Injection
Dosage and strength : Injection, 80mg:2ml, 40mg:2ml
Packaging : 10 x 10 amps/box, 10 amps/box
Standard : BP/USP
Dossier : Ready to submit
This product is clarity, or almost colorless clarity liquid.
Indications and Dosages
➤➤To treat serious bacterial infections caused by aerobic gram-negative organisms and some gram-positive organisms, including Citrobacter species, Enterobacter species, Escherichia coli, Klebsiella species, Proteus species, Pseudomonas aeruginosa, Serratia species, Staphylococcus aureus, and many strains of Streptococcus species
I.V. INFUSION, I.M. INJECTION
Adults and adolescents. 1 to 1.7 mg/kg every 8 hr or 4-7 mg/kg every 24 hours.
Children. 2 to 2.5 mg/kg every 8 hr.
Infants. 2.5 mg/kg every 8 to 16 hr.
Premature or full-term neonates up to age
1 week. 2.5 mg/kg every 12 to 24 hr.
INTRATHECAL (INTRALUMBAR OR INTRAVENTRICULAR) INJECTION
Adults and adolescents. 4 to 8 mg daily.
Infants and children age 3 months and over. 1 to 2 mg daily.
➤➤To treat uncomplicated UTI
I.V. INFUSION, I.M. INJECTION
Adults and adolescents weighing more than 60 kg (132 lb). 160 mg once daily or
80 mg every 12 hr.
Adults and adolescents weighing less than 60 kg. 3 mg/kg once daily or 1.5 mg/kg
every 12 hr.
DOSAGE ADJUSTMENT Supplemental dose of 1 to 1.7 mg/kg (2 to 2.5 mg/kg for children) given by I.M. injection or I.V. infusion after hemodialysis, based on infection severity.
Mechanism of Action
Binds to negatively charged sites on the outer cell membrane of bacteria, thereby disrupting the membrane’s integrity. Gentamicin also binds to bacterial ribosomal subunits and inhibits protein synthesis. Both actions lead to cell death.
Don’t administer gentamicin through same I.V. line as other drugs, especially betalactam
antibiotics (penicillins and cephalosporins), because substantial mutual inactivation may occur. Give drugs through separate sites.
Hypersensitivity or serious toxic reaction to other aminoglycosides, hypersensitivity to gentamicin or its components
aminoglycosides (concurrent use of two or more): Decreased bacterial uptake of each drug, increased risk of ototoxicity and nephrotoxicity
cephalosporins, enflurane, methoxyflurane, vancomycin: Increased risk of nephrotoxicity loop diuretics: Increased risk of ototoxicity and nephrotoxicity
neuromuscular blockers: Prolonged respiratory depression, increased neuromuscular blockade
penicillins: Inactivation of gentamicin by certain penicillins, increased risk of nephrotoxicity
CNS: Acute organic mental syndrome, confusion, depression, fever, headache, increased protein in cerebrospinal fluid lethargy, myasthenia gravis–like syndrome, neurotoxicity (dizziness, hearing loss, tinnitus, vertigo), peripheral neuropathy or encephalopathy (muscle twitching, numbness, seizures, skin tingling), pseudotumor cerebri
CV: Hypertension, hypotension, palpitations
EENT: Blurred vision, increased salivation, laryngeal edema, ototoxicity, stomatitis,
GI: Anorexia, nausea, splenomegaly, transient hepatomegaly, vomiting
HEME: Anemia, eosinophilia, granulocytopenia, increased or decreased reticulocyte count, leukopenia, thrombocytopenia
MS: Arthralgia, leg cramps
RESP: Pulmonary fibrosis, respiratory depression
SKIN: Alopecia, generalized burning sensation, pruritus, purpura, rash, urticaria
Other: Anaphylaxis, injection-site pain, superinfection, weight loss
Gentamicin is a broad spectrum aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
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