Respiratory Tract Infections Cefradine Antibiotic 0. 0.5g - 1.0g Dry Powder

Respiratory Tract Infections Cefradine Antibiotic 0. 0.5g - 1.0g Dry Powder

Product : Cefradine for Injection

Specification : 0.5g; 1.0g;

Standard : BP, USP

Indications :

Cefradine is used in the following instances:

Respiratory tract infections (such as tonsillitis, pharyngitis, and lobar pneumonia) caused by group A beta-hemolytic streptococci and S. pneumoniae (formerly D. pneumonia).[note 1]

Otitis media caused by group A beta-hemolytic streptococci, S. pneumoniae (formerly D. pneumoniae), H. influenzae, and staphylococci.

Skin and skin structure infections caused by staphylococci (penicillin-susceptible and penicillin-resistant) and beta-hemolytic streptococci.

Urinary tract infections, including prostatitis, caused by E. coli, P. mirabilis, Klebsiella species, and enterococci (including Enterococcus faecalis). The high concentrations of cephradine achievable in the urinary tract will be effective against many strains of enterococci for which disc susceptibility studies indicate relative resistance.

Mechanism of action :

Cefradine is a first generation cephalosporin antibiotic with a spectrum of activity similar to Cefalexin. Cefradine, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Cefradine interferes with an autolysin inhibitor.