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3543-75-7 High Purity Active Pharmaceutical Ingredients Bendamustine Hydrochloride

3543-75-7 High Purity Active Pharmaceutical Ingredients Bendamustine Hydrochloride

3543-75-7 High Purity Active Pharmaceutical Ingredients Bendamustine Hydrochloride

Product Details:

Place of Origin: China
Brand Name: Newlystar
Certification: GMP
Model Number: USP, BP

Payment & Shipping Terms:

Minimum Order Quantity: 25kg
Price: Negotiation
Packaging Details: 10kg, 25kg per drum
Delivery Time: 30days
Payment Terms: L/C, T/T
Supply Ability: Ten tons per month
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Detailed Product Description
Product: Bendamustine Hydrochloride API CAS NO.: 3543-75-7
Purity: 99.0% Usage: Anti Cancer

3543-75-7 High Purity Active Pharmaceutical Ingredients Bendamustine Hydrochloride

 

 

Bendamustine Hydrochloride API

CAS NO. 3543-75-7

Purity : 99.0%

 

Description :

Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.

 

 

Indication :

Bendamustine is indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
 

Pharmacodynamics :

No mean changes in QTc interval greater than 20 milliseconds were detected up to one hour post-infusion.
 

Mechanism of action :

Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.

Contact Details
Newlystar (Ningbo) Medtech Co.,Ltd.

Contact Person: Luke Liu

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