|801-2, Jindong Mansion, No. 536 Xueshi Road, Yinzhou, Ningbo 315100, P.R.Chinafirstname.lastname@example.org|
|Place of Origin:||China|
|Minimum Order Quantity:||300, 000 amps|
|Packaging Details:||10 x 10amps/box|
|Supply Ability:||one million amps per day|
|Standard:||BP, USP||Packing:||10 X 10amps/box|
small volume injection,
Furosemide Injection Small Volume Parenteral antihypertensive diuretic 20mg/2ml
Product : Furosemide Injection
Specification : 20mg/2ml
Standard : BP, USP
Packing : 10 x 10amps/box
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency.
Indications and Dosages :
➤➤To reduce edema caused by cirrhosis, heart failure, and renal disease, including nephrotic syndrome
oral solution, tablets
Adults. 20 to 80 mg as a single dose, increased by 20 to 40 mg every 6 to 8 hr until desired response occurs. Maximum: 600 mg daily.
Children. 2 mg/kg as a single dose, increased by 1 to 2 mg/kg every 6 to 8 hr until desired response occurs. Maximum: 6 mg/kg/dose.
i.v. infusion, i.v. or i.m. injection
Adults. 20 to 40 mg as a single dose, increased by 20 mg every 2 hr until desired response occurs.
Children. 1 mg/kg as a single dose, increased by 1 mg/kg every 2 hr until desired response occurs. Maximum: 6 mg/kg/dose.
dosage adjustment Initial single dose limited to 20 mg for elderly patients.
➤➤To manage mild to moderate hypertension, as adjunct to treat acute pulmonary edema and hypertensive crisis
oral solution, tablets
Adults. Initial: 40 mg twice daily, adjusted until desired response occurs. Maximum: 600 mg daily.
i.v. infusion or injection
Adults with normal renal function. 40 to 80 mg as a single dose over several minutes.
Adults with acute renal failure or pulmonary edema. 100 to 200 mg as a single dose over several minutes.
dosage adjustment For patients with acute pulmonary edema without hypertensive crisis, dosage reduced to 40 mg followed by 80 mg 1 hr later if therapeutic response doesn’t occur.
Route Onset Peak Duration
P.O. 20–60 min 1–2 hr 6–8 hr
I.V. 5 min In 30 min 2 hr
I.M. 30 min Unknown 2 hr
Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.
Mechanism of action :
Furosemide, a loop diuretic, inhibits water reabsorption in the nephron by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. This is achieved through competitive inhibition at the chloride binding site on the cotransporter, thus preventing the transport of sodium from the lumen of the loop of Henle into the basolateral interstitium. Consequently, the lumen becomes more hypertonic while the interstitium becomes less hypertonic, which in turn diminishes the osmotic gradient for water reabsorption throughout the nephron. Because the thick ascending limb is responsible for 25% of sodium reabsorption in the nephron, furosemide is a very potent diuretic.
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