|801-2, Jindong Mansion, No. 536 Xueshi Road, Yinzhou, Ningbo 315100, P.R.Chinafirstname.lastname@example.org|
|Place of Origin:||China|
|Model Number:||120mg/5ml, 250mg/5ml; 100ml|
|Minimum Order Quantity:||50, 000 bottles|
|Packaging Details:||one bottle/box|
|Payment Terms:||L/C, T/T|
|Supply Ability:||50, 000 bottles per day|
|Product:||Paracetamol For Oral Suspension||Specification:||120mg/5ml, 250mg/5ml; 100ml|
|Standard:||BP, USP||Packing:||One Bottle/box|
Paracetamol Oral Suspension Oral Medications / Paracetamol Syrup For Child
Product : Paracetamol for Oral Suspension
Specification : 120mg/5ml, 250mg/5ml; 100ml
Standard : BP, USP
Packing : one bottle/box
Each 5ml of oral suspension contains 250mg of paracetamol. The product is packaged in amber Type III glass bottles with high density polypropylene child resistant tamper evident caps with polyethylene liners, in pack sizes of 100ml and 200ml of oral suspension. The bottles are packed with a spoon with a 2.5ml and 5ml measure and Patient Information Leaflets into cardboard outer cartons.
Indications and Usage
For the treatment of mild to moderate pain, including headache, migraine, neuralgia, toothache, sore throat, period pains, aches and pains.
For the reduction of fever and to be used as an adjunctive treatment to relieve symptoms of cold and flu.
Acetaminophen (USAN) or Paracetamol (INN) is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or accidental overdoses are not uncommon. Acetaminophen, unlike other common analgesics such as aspirin and ibuprofen, has no anti-inflammatory properties or effects on platelet function, and it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs or NSAIDs. At therapeutic doses acetaminophen does not irritate the lining of the stomach nor affect blood coagulation, kidney function, or the fetal ductus arteriosus (as NSAIDs can). Like NSAIDs and unlike opioid analgesics, acetaminophen does not cause euphoria or alter mood in any way. Acetaminophen and NSAIDs have the benefit of being completely free of problems with addiction, dependence, tolerance and withdrawal. Acetaminophen is used on its own or in combination with pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, doxylamine, codeine, hydrocodone, or oxycodone.
Mechanism of action
Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.
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