|801-2, Jindong Mansion, No. 536 Xueshi Road, Yinzhou, Ningbo 315100, P.R.Chinaemail@example.com|
|Place of Origin:||China|
|Model Number:||50ml:8mg:0.45g, 100ml:8mg:0.9g|
|Minimum Order Quantity:||100, 000 bottles|
|Packaging Details:||100 / 50 bottles/carton|
|Payment Terms:||L/C, T/T|
|Supply Ability:||500, 000 bottles per day|
|Product:||Ondansetron Hydrochloride And Sodium Chloride Injetion||Specification:||50ml:8mg:0.45g, 100ml:8mg:0.9g|
|Standard:||BP, USP||Packing:||100 / 50 Bottles/carton|
Large Volume Infusion
Ondansetron Hydrochloride LVP Medical , Large Volume Infusion For Vomiting
Product : Ondansetron Hydrochloride and Sodium Chloride Injetion
Specification : 50ml:8mg:0.45g, 100ml:8mg:0.9g
Standard : BP, USP
Packing : 100 / 50 bottles/carton
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
For the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, postoperation, and radiation. Also used for the treatment of postoperative nausea and vomiting.
Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serontonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery, and centrally in the chemoreceptor trigger zone of the area postrema. The temporal relationship between the emetogenic action of emetogenic drugs and the release of serotonin, as well as the efficacy of antiemetic agents suggest that chemotherapeutic agents release serotonin from the enterochromaffin cells of the small intestine by causing degenerative changes in the GI tract. The serotonin then stimulates the vagal and splanchnic nerve receptors that project to the medullary vomiting center, as well as the 5-HT3 receptors in the area postrema, thus initiating the vomiting reflex, causing nausea and vomiting.
Mechanism of action
Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.
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