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Amoxicillin and Clavulanate Potassium Tablets 250mg+125mg, 500mg+125mg, 875mg+125mg Oral Medications Antibiotics

Amoxicillin and Clavulanate Potassium Tablets 250mg+125mg, 500mg+125mg, 875mg+125mg Oral Medications Antibiotics

Amoxicillin and Clavulanate Potassium Tablets 250mg+125mg, 500mg+125mg, 875mg+125mg Oral Medications Antibiotics

Product Details:

Place of Origin: China
Brand Name: Newlystar
Certification: GMP
Model Number: 250mg+125mg, 500mg+125mg, 875mg+125mg

Payment & Shipping Terms:

Minimum Order Quantity: 300, 000 tablets
Price: Negotiation
Packaging Details: 10's/blister
Delivery Time: 45days
Payment Terms: L/C, T/T
Supply Ability: One million pills per day
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Detailed Product Description
Product: Amoxicillin And Clavulanate Potassium Tablets Specification: 250mg+125mg, 500mg+125mg, 875mg+125mg
Standard: BP, USP Packing: 10's/blister

Amoxicillin and Clavulanate Potassium Tablets 250mg+125mg, 500mg+125mg, 875mg+125mg Oral Medications Antibiotics

 

Product : Amoxicillin and Clavulanate Potassium Tablets

Specification : 250mg+125mg, 500mg+125mg, 875mg+125mg

Standard : BP, USP

Packing : 10's/blister

 

Description :

Amoxicillin is a broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation.

Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase.

 

Indication :

For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).

 

Pharmacodynamics

Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of β-lactamase-producing resistant organisms, including E. coli, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production.

 

Mechanism of action

Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.

Contact Details
Newlystar (Ningbo) Medtech Co.,Ltd.

Contact Person: Luke Liu

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