Lyophilized Powder Omeprazole Sodium Injection 40mg Digestive System Medicine Anti Acid

Esomeprazole 40 mg powder for solution for injection/infusion is indicated in adults for:

• gastric antisecretory treatment when the oral route is not possible, such as:

- gastroesophageal reflux disease (GERD) in patients with oesophagitis and/or severe symptoms of reflux

- healing of gastric ulcers associated with NSAID therapy

- prevention of gastric and duodenal ulcers associated with NSAID therapy, in patients at risk.

• prevention of rebleeding following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers.

Esomeprazole SUN 40 mg powder for solution for injection/infusion is indicated in children and adolescents aged 1-18 years for:

• gastric antisecretory treatment when the oral route is not possible, such as:

− gastroesophageal reflux disease (GERD) in patients with erosive reflux esophagitis and/or severe symptoms of reflux.

Mechanism of Action :

Omeprazole interferes with gastric acid secretion by inhibiting the hydrogen potassium -adenosine triphosphatase (H + K + -ATPase) enzyme system, or proton pump, in gastric parietal cells. Normally, the proton pump uses energy from hydrolysis of adenosine triphosphate to drive hydrogen (H+) and chloride (Cl−) out of parietal cells and into the stomach lumen in exchange for potassium (K+), which leaves the stomach lumen and enters parietal cells. After this exchange, H+ and Cl− combine in the stomach to form hydrochloric acid (HCl), as shown below left. Omeprazole irreversibly blocks the exchange of intracellular H+ and extracellular K+, as shown below right. By preventing H+ from entering the stomach lumen, omeprazole keeps additional HCl from forming.