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40 mg Lyophilized Powder Injection , Omeprazole Sodium for Injection

40 mg Lyophilized Powder Injection , Omeprazole Sodium for Injection

    • 40 mg Lyophilized Powder Injection , Omeprazole Sodium for Injection
  • 40 mg Lyophilized Powder Injection , Omeprazole Sodium for Injection

    Product Details:

    Place of Origin: China
    Brand Name: Newlystar
    Certification: GMP
    Model Number: Lyophilized, 40mg

    Payment & Shipping Terms:

    Minimum Order Quantity: 100, 000 vials
    Price: Negotiation
    Packaging Details: 50vials/box
    Delivery Time: 45days
    Payment Terms: L/C, T/T
    Supply Ability: 300, 000 vials per day
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    Detailed Product Description
    Product: Omeprazole Sodium For Injection Specification: Lyophilized, 40mg
    Standard: BP, USP Packing: 50vials/box
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    40 mg Lyophilized Powder Injection , Omeprazole Sodium for Injection

     

     

    Product : Omeprazole Sodium for Injection

    Specification : Lyophilized, 40mg

    Standard : BP, USP

    Packing : 50vials/box

     

     

    Description :

    Omeprazole is a highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell.

     

    Indications and Dosages :

    ➤➤To treat gastroesophageal reflux disease (GERD) without esophageal lesions, to prevent erosive esophagitis

    delayed-release capsules, delayed-release tablets, oral suspension

    Adults. 20 mg daily for 4 wk.

    ➤➤To treat GERD with erosive esophagitis

    delayed-release capsules, delayed-release tablets, oral suspension

    Adults. 20 mg daily for 4 to 8 wk.

    ➤➤To treat pediatric GERD and maintenance of healing of erosive esophagitis

    delayed-release capsules (prilosec), oral suspension(prilosec)

    Children age 1 to 16 years of age weighing 20 kg (44 lb) or more. 20 mg daily.

    Children age 1 to 16 weighing 10 kg (22 lb) to less than 20 kg (44 lb). 10 mg daily.

    Children age 1 to 16 weighing 5 kg (11 lb) to less than 10 kg (22 lb). 5 mg daily.

    ➤➤To provide short-term treatment of active benign gastric ulcer

    delayed-release capsules

    Adults. 40 mg daily for 4 to 8 wk.

    delayed-release tablets

    Adults. 20 mg daily for 4 to 8 wk, increased to 40 mg daily, as needed.

    ➤➤To treat duodenal or gastric ulcer associated with Helicobacter pylori

    delayed-release capsules, oral suspension

    Adults. 40 mg daily, with clarithromycin for 14 days, followed by 20 mg daily alone for another 14 days. Or, 20 mg twice daily with amoxicillin for 14 days. Or, 20 mg twice daily with amoxicillin and clarithromycin for 10 days.

    delayed-release tablets

    Adults. 20 mg twice daily. with clarithromycin and amoxicillin or metronidazole for 7 days, followed by 20 mg daily for up to 3 wk (for duodenal ulcer) or 20 to 40 mg daily for up to 12 wk (for gastric ulcer).

    ➤➤To provide long-term treatment of gastric hypersecretory conditions, such as multiple endocrine adenoma syndrome, systemic mastocytosis, and Zollinger-Ellison syndrome

    delayed-release capsules, delayed-release tablets

    Adults. 60 mg daily or in divided doses, as prescribed. Maximum: 120 mg three times daily.

    Route     Onset     Peak     Duration

    P.O.          1 hr      In 2 hr   72–96 hr

     

    Pharmacodynamics

    After oral administration, the onset of the anti-secretory effect of omeprazole occurs within one hour and maximum effect occurring within two hours. At 24 hours, inhibition of secretion is approximately 50% of maximum and duration of inhibition lasts up to 72 hours. Although omeprazole has a very short plasma half-life, the anti-secretory effect lasts for a long time due to prolonged binding to parietal H+/K+ ATPase enzyme. When the drug has been discontinued, secretory activity will return to baseline over 3-5 days. The inhibitory effect of omeprazole on acid secretion increases with repeated once-daily dosing, reaching a plateau after four days. In studies involving more than 200 patients, serum gastrin levels increased during the first 1 to 2 weeks of once-daily administration of therapeutic doses of omeprazole in parallel with inhibition of acid secretion. Systemic effects of omeprazole in the CNS, cardiovascular and respiratory systems have not been found to date.

     

    Mechanism of action

    Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, omeprazole blocks the final step in acid production, thus reducing gastric acidity.

    Contact Details
    Newlystar (Ningbo) Medtech Co.,Ltd.

    Contact Person: Luke Liu

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