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Mycophenolate Mofetil Dispersible Tablets Film-coated, 250mg, 500mg Oral Medications

Mycophenolate Mofetil Dispersible Tablets Film-coated, 250mg, 500mg Oral Medications

  • Mycophenolate Mofetil Dispersible Tablets Film-coated, 250mg, 500mg Oral Medications
Mycophenolate Mofetil Dispersible Tablets Film-coated, 250mg, 500mg Oral Medications
Product Details:
Place of Origin: China
Brand Name: Newlystar
Certification: GMP
Model Number: Film-coated, 250mg, 500mg
Payment & Shipping Terms:
Minimum Order Quantity: 500, 000 tablets
Price: Negotiation
Packaging Details: 10’s/blister
Delivery Time: 45days
Payment Terms: L/C, T/T
Supply Ability: One million pills per day
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Detailed Product Description
Product: Mycophenolate Mofetil Dispersible Tablets Specification: Film-coated, 250mg, 500mg
Standard: BP, USP Packing: 10’s/blister
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Mycophenolate Mofetil Dispersible Tablets Film-coated, 250mg, 500mg Oral Medications

 

Product : Mycophenolate Mofetil Dispersible Tablets

Specification : Film-coated, 250mg, 500mg

Standard : BP, USP

Packing : 10’s/blister

 

Description :

Mycophenolate mofetil is the 2-morpholinoethyl ester of mycophenolic acid (MPA), an immunosuppressive agent, inosine monophosphate dehydrogenase (IMPDH) inhibitor.

 

Indication

For the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. Mycophenolate mofetil should be used concomitantly with cyclosporine and corticosteroids.

 

Pharmacodynamics

Mycophenolate mofetil is a prodrug of mycophenolic acid (MPA), an antibiotic substance derived from Penicillium stoloniferum. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites.

 

Mechanism of action

Mycophenolate mofetil is hydrolyzed to form mycophenolic acid (MPA), which is the active metabolite. MPA is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. Because T- and B-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines, whereas other cell types can utilize salvage pathways, MPA has potent cytostatic effects on lymphocytes. MPA inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic effects of MPA on lymphocytes. MPA also suppresses antibody formation by B-lymphocytes. MPA prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection. Mycophenolate mofetil did not inhibit early events in the activation of human peripheral blood mononuclear cells, such as the production of interleukin-1 (IL-1) and interleukin-2 (IL-2), but did block the coupling of these events to DNA synthesis and proliferation.

Contact Details
Newlystar (Ningbo) Medtech Co.,Ltd.

Contact Person: Mr. Luke Liu

Tel: 86--57487019333

Fax: 86-574-8701-9298

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