Ranitidine Hydrochloride Oral Medications Ranitidine Tablets 150 mg 300mg

Ranitidine Hydrochloride Oral Medications Ranitidine Tablets 150 mg 300mg

Product : Ranitidine Tablets

Specification : Film-coated, 150mg, 300mg

Standard : BP, USP

Packing : 10’s/blister

Description :

Ranitidine hydrochloride belongs to a class of medicines called H2-receptor antagonists. This medicine works by reducing the amount of acid in your stomach. It is used to treat gastrointestinal ulcers as well as to relieve heartburn and indigestion.

Indication

Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).

Pharmacodynamics

Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.

Mechanism of action

The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.