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Doxazosin Mesylate Tablets 2mg Oral Medications

Doxazosin Mesylate Tablets 2mg Oral Medications

    • Doxazosin Mesylate Tablets 2mg Oral Medications
  • Doxazosin Mesylate Tablets 2mg Oral Medications

    Product Details:

    Place of Origin: China
    Brand Name: Newlystar
    Certification: GMP
    Model Number: 2mg

    Payment & Shipping Terms:

    Minimum Order Quantity: 300, 000 tablets
    Price: Negotiation
    Packaging Details: 10's/blister
    Delivery Time: 45days
    Payment Terms: L/C, T/T
    Supply Ability: One million pills per day
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    Detailed Product Description
    Product: Doxazosin Mesylate Tablets Specification: 2mg
    Standard: BP, USP Packing: 10's/blister
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    Doxazosin Mesylate Tablets 2mg Oral Medications

     

    Product : Doxazosin Mesylate Tablets

    Specification : 2mg

    Standard : BP, USP

    Packing : 10's/blister

     

    Description :

    Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. It may be used to mild to moderate hypertension and in the management of symptomatic benign prostatic hyperplasia (BPH). α1-Receptors mediate contraction and hypertrophic growth of smooth muscle cells. Antagonism of these receptors leads to smooth muscle relaxation in the peripheral vasculature and prostate gland.

     

    Indication

    For treatment and management of mild to moderate hypertension and urinary obstruction symptoms caused by BPH.

     

    Pharmacodynamics

    Doxazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Doxazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Doxazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Doxazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Doxazosin results from a decrease in systemic vascular resistance and the parent compound Doxazosin is primarily responsible for the antihypertensive activity.

     

    Mechanism of action

    Doxazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

    Contact Details
    Newlystar (Ningbo) Medtech Co.,Ltd.

    Contact Person: Luke Liu

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