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Antineoplastic Lyophilized Powder Injection / Daunorubicin Hydrochloride Injection 20mg Anti cancer

Antineoplastic Lyophilized Powder Injection / Daunorubicin Hydrochloride Injection 20mg Anti cancer

Antineoplastic Lyophilized Powder Injection / Daunorubicin Hydrochloride Injection 20mg Anti cancer

Product Details:

Place of Origin: China
Brand Name: Newlystar
Certification: GMP
Model Number: Lyophilized, 20mg

Payment & Shipping Terms:

Minimum Order Quantity: 10000 vials
Price: Negotiation
Packaging Details: 10 vials/box
Delivery Time: 45days
Payment Terms: L/C, T/T
Supply Ability: 50, 000 vials per day
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Detailed Product Description
Product: Daunorubicin Hydrochloride For Injection Specification: Lyophilized, 20mg
Standard: BP, USP Packing: 10 Vials/box

Antineoplastic Lyophilized Powder Injection / Daunorubicin Hydrochloride Injection 20mg Anti cancer

 

 

Product : Daunorubicin Hydrochloride for Injection

Specification : Lyophilized, 20mg

Standard : BP, USP

Packing : 10 vials/box

 

Description :

Doxorubicin Hydrochloride for Injection, is a sterile red-orange lyophilized powder for intravenous use only, is available in 10, 20 and 50 mg single dose vials.

 

Indication and dosage :

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

 

To treat acute lymphocytic leukemia

45 mg/m2 daily for first 3 days of a 32-day course of vincristine, prednisone, and asparaginase combination therapy

 

To treat acute nonlymphocytic leukemia

45 mg/m2 daily for first 3 days of first course of cytarabine combination therapy and first 2 days of second course of cytarabine combination therapy

 

Pharmacodynamics :

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

 

Mechanism of action

Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Contact Details
Newlystar (Ningbo) Medtech Co.,Ltd.

Contact Person: Luke Liu

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