|Place of Origin:||China|
|Model Number:||Lyophilized, 20mg, 40mg|
|Minimum Order Quantity:||100, 000 vials|
|Payment Terms:||L/C, T/T|
|Supply Ability:||300, 000 vials per day|
|Product:||Esomeprazole Sodium For Injection||Specification:||Lyophilized, 20mg, 40mg|
|Standard:||In - House||Packing:||50vials/box|
Lyophilized Powder Injection / Proton Pump Inhibitor Anti Acid Esomeprazole Sodium For Injection
Product : Esomeprazole Sodium For Injection
Specification : Lyophilized, 20mg, 40mg
Standard : In - house
Packing : 50vials/box
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+- ATPase in the gastric parietal cell.
Esomeprazole Sodium for Injection is supplied as a freeze-dried white to off-white powder containing 20 mg or 40 mg of esomeprazole per single-use vial.
Esomeprazole Sodium for Injection contains esomeprazole sodium 21.3 mg or 42.5 mg equivalent to esomeprazole 20 mg or 40 mg, edetate disodium 1.5 mg and sodium hydroxide q.s. for pH adjustment.
Indication and dosage :
➤➤To treat GERD in a patient with a history of erosive esophagitis who can’t take the drug by mouth
Adults. 20 to 40 mg daily infused over 10 to 30 min.
Children weighing 55 kg (121 lbs) or more. 20 mg daily infused over 10 to 30 min. lbs). 10 mg daily infused over 10 to 30 min.
Children ages 1 month to less than 1 year. 0.5 mg/kg daily infused over 10 to 30 min. dosage adjustment For adult patient with severe liver impairment, dosage should not exceed 20 mg daily.
Adults. 20 or 40 mg daily given over no less than 3 min.
Esomeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Esomeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase at the secretory surface of the gastric parietal cell. By doing so, it inhibits acid secretion into the gsatric lumen. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.
Mechanism of action
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.