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Terazosin Hydrochloride Capsules 1mg, 2mg, 5mg, 10mg Oral Medications

Terazosin Hydrochloride Capsules 1mg, 2mg, 5mg, 10mg Oral Medications

  • Terazosin Hydrochloride Capsules 1mg, 2mg, 5mg, 10mg Oral Medications
Terazosin Hydrochloride Capsules 1mg, 2mg, 5mg, 10mg Oral Medications
Product Details:
Place of Origin: China
Brand Name: Newlystar
Certification: GMP
Model Number: 1mg, 2mg, 5mg, 10mg
Payment & Shipping Terms:
Minimum Order Quantity: 500, 000 capsules
Price: Negotiation
Packaging Details: 6’s/blister
Delivery Time: 45days
Payment Terms: L/C, T/T
Supply Ability: One million pills per day
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Detailed Product Description
Product: Terazosin Hydrochloride Capsules Specification: 1mg, 2mg, 5mg, 10mg
Standard: In - House Packing: 6’s/blister
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Terazosin Hydrochloride Capsules 1mg, 2mg, 5mg, 10mg Oral Medications

 

Product : Terazosin Hydrochloride Capsules

Specification : 1mg, 2mg, 5mg, 10mg

Standard : In - house

Packing : 6’s/blister

 

Description :

Terazosin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH). It also acts to lower blood pressure, so it is a drug of choice for men with hypertension and prostate enlargement. It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

 

Indication

For the treatment of symptomatic BPH and mild to moderate hypertension.

 

Pharmacodynamics

Terazosin, classified as a quinazoline, is similar to doxazosin and prazosin. As an α-adrenergic blocking agent, terazosin is used to treat hypertension and BPH. Terazosin produces vasodilation and reduces peripheral resistance but in general has only a slight effect on cardiac output. The antihypertensive effect with chronic dosing is not usually accompanied by reflex tachycardia.

 

Mechanism of action

In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. α1-Receptors are 7-transmembrane domain receptors coupled to G proteins, Gq/11. Three α1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: α1A (chromosome 8), α1B (chromosome 5), and α1D (chromosome 20). Terazosin is the first α1-receptor antagonist to demonstrate selectivity for the α1A-receptor. All three receptor subtypes appear to be involved in maintaining vascular tone. The α1A-receptor maintains basal vascular tone while the α1B-receptor mediates the vasocontrictory effects of exogenous α1-agonists. Activation of α1-receptors activates Gq-proteins, which results in intracellular stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2+ from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and subsequent vasoconstriction. Terozosin produces its pharmacological effects by inhibiting α1A-receptor activation. Inhibition of these receptors in the vasculature and prostate results in muscle relaxation, decreased blood pressure and improved urinary outflow in symptomatic benign prostatic hyperplasia.

Contact Details
Newlystar (Ningbo) Medtech Co.,Ltd.

Contact Person: Mr. Luke Liu

Tel: 86--57487019333

Fax: 86-574-8701-9298

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